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Biotechnology

(Plant Gene Treatment)

Ullah, Hemayet

Dakshanamurthy, Siva, (Georgetown University)

RACK-1 Gene Modification for Drought Protection in Plants

Description: Drought damage to food and biofuel crops is a serious agricultural concern. The current methods to combat drought-induced crop deterioration are costly, highly sensitive to light, or provide incomplete protection. This invention identifies a series of novel compounds that inhibit the function of the RACK1A gene. Inhibiting the RACK1A produces crops with improved drought resistance, and may also protect plants from other environmental stressors.  The technology is a non-GMO solution.

Status: Patent Pending, Co-Commercialized with Georgetown University

Visit: <Demonstration Video> <Marketing Document> <WIPO Application Page> <Georgetown External Marketing Page>

Computer Sciences

(Software, Ground Penetrating Radar)

Anderson, John

Ode, Oludotun

Ogworonjo, Henry

Adaptive Statistically Based Algorithms for Ground Penetrating Radar Imaging Under Varied Environmental Conditions

Description: Howard University (HU) has developed statistically based algorithms for accurately reconstructing ground penetrating radar (GPR) images that can be implemented in near real time. Note, the pixel value of a GPR image is an estimate of the reflection coefficient for the corresponding volume in a scene-of-interest (SOI).The image reconstructing algorithms are based on the maximum-a-posteriori (MAP) method, which is an estimation method that provides a means for incorporating prior information through a judicious choice of the prior probability density function for the unknown reflection coefficients. In applications such as landmine and IED detection, the prior information is that a typical SOI contains few scatterers which means that a large percentage of the unknown reflection coefficients are zero or near zero.  By incorporating the known “sparcity” of the reflection coefficients, improved GPR images can be reconstructed by the developed MAP algorithms.  Specifically the reconstructed GPR images identify the targets-of-interest, while concurrently reducing ever present clutter and noise.

Status: Patent Pending

Visit: <Marketing Document>

Computer Sciences

(Software, Healthcare)

Anderson, John

PET Based Voxel-Resolution Myocardial Blood Flow Analysis

Description: The ability to accurately quantify myocardial blood flow (MBF) is critical to diagnosing the extent and severity of coronary artery disease. This algorithm, which is designed for use with a PET scanner, can measure absolute myocardial blood flow quantitatively. Specifically, it combines pharmacological kinetics and voxel (volumetric pixel) myocardial blood flow.

Status: Patent No. 9,149,244

Visit: <WIPO Application Page> <Marketing Document> <USPTO Page>

Computer Sciences

(Software, Mobile Applications)

Burge, Legand

Context-Aware Computing Architecture and Software Platform

Description: Advertising and service industries are always seeking new ways to connect with mobile application users as they navigate through a defined space (i.e. college campus, shopping mall). This invention provides a platform for media-rich, context-aware mobile applications. The mobile-device user can receive specific messages based on the user’s location without explicit user intervention.

Status: Patent No. 8,751,743, Application Published

Visit: <Issued Patent> <WIPO Application Page> <Marketing Document>

Computer Sciences

(Hardware, Processors)

Gloster, Clay;

Gay, Wanda;

Amoo, Michaela

Multiple-Memory Application-Specific Digital Signal Processor

Description: A customizable, configurable multiple-memory Application-Specific Digital Signal Processor (ASDSP) capable of achieving high input-high output computational capabilities, and providing a significant increase in input/output data bandwidth.

Status: Patent No. 9,111,068, Application Published

Visit: <WIPO Application Page> <Marketing Document> <USPTO Page>

Computer Sciences

(Software, Cyber Security)

Kim, Charles A Method for Cyber-Robust Computer Control System

Description:Howard University has developed a cyber-resilience approach that makes networked computer control systems substantially immune to cyber incidents. Cyber incidents may be originated from malicious cyber attackers, random or design hardware/software problems in the computer controllers, sabotage from a disgruntled employee, or inadvertent mistakes. The inventive approach includes a redundant computer controller assigned a duplicative control function in a different hardware using different software, e.g., using a different programming language, to insure cyber fail-safe operation even under the situation of cyber attack and infiltration.

Status: Patent Pending

Visit: <Marketing Document>

Consumer Products

(Clothing, Undergarments)

Wynn, Karen

Women’s Hygienic Underwear

Description: Howard University’s new technology is an undergarment with a unique pocket system for girls and women who utilize menstrual or light to moderate urinary incontinence pads. This patent is intended to be utilized in most contemporary styles of women’s undergarments.

Status: Patent No. D632,055, Non-Exclusive License with Salk, Inc.

Visit: <USPTO Page> <Marketing Document>

Electrical Engineering

(Architectural Lighting Technology)

Kim, Charles

Architectural, LED Lighting Array Control System

Description: This invention allows one LED within a large-scale lighting array to control the entire system. As a result, it eliminates the need for expensive and cumbersome wiring and controller banks traditionally used in large LED-lighting arrays. This technology’s potential applications include commercial signage, architectural lighting, and large holiday light displays.

Status: Patent No. 8,525,421, Application Published

Visit: <USPTO Page> <Marketing Document>

Electrical Engineering

(Electrical Fault Detection)

Kim, Charles

Method of Detection of Intermittent Faults in Electrical Wiring Via PLC Data

Description: Intermittent faults are difficult to detect, but if left untreated, can lead to permanent faults resulting in dangerous and costly consequences. This detection system injects a signal at one location of the electrical wire system and diagnoses the health status of the system by measuring the error rate of the signal at another location. If an error is found, an alarm or annunciation is activated to alert the user of an intermittent fault. This invention can be adapted to a variety of existing electrical systems. Potential applications include aerospace, automotive, nautical, and construction wiring systems.

Status: Patent No. 8,102,779, Patent No. 8,050,002, & Patent No. 8,711,711.

Visit: <USPTO Page> <Marketing Document>

Electrical Engineering

(Electrical Fault Detection)

Kim, Charles

Sub-Cycle Preemptive Fault Location in the Power Grid

Description: The technology provides electric power providers the ability to anticipate power failures and act timely to prevent power outages. The new system records spurious signals that occur in the course of regular power-grid activity. Irregular, short-term drops in signal level are recorded and logged. These drops typically vanish in less than 10 milliseconds. The new system simulates the application of a ghost signal in the grid with the objective of finding the type of imaginary signal that re-creates the above mentioned spurious drop.

Status: Patent No. 8,941,387, Application Published, Co-Commercialized with San Diego Gas and Electric

Visit: <USPTO Page> <PowerPoint Presentation> <WIPO Application Page>

Electrical Engineering

(Electrical Fault Detection)

Kim, Charles

System and Method of Detecting and Locating Intermittent Electrical Faults in Electrical Systems

Description: Signals are transmitted from at least one transmitter that is positioned in an electrical network. The signals that have been transmitted are received a single receiver positioned within the electrical network. At the single receiver, the received signals are analyzed and a determination from the analyzing the received signals is made as to whether a fault has occurred in the electrical network and the approximate location of the fault.

Status: Patent No. 9,215,045

Visit: <USPTO Page>

Electrical Engineering

(Residential Energy Efficiency)

Momoh, James

Customer Power Quality Monitor

Description: An innovative scheme that uses simple but advanced computational intelligence techniques coupled with systems modeled to achieve the monitoring and control of power quality within a residence.

Status: Patent No. 8,244,406.

Visit: <USPTO Page> <Marketing Document>

Green Energy Technology

(Coal, Clean Coal, Mercury Elimination)

Aluko, Mobolaji;

Ekechukwu, Kenneth;

Akers, David (CQ, Inc.)

Lebowitz; Howard (CQ, Inc.)

 

Process for Removal of Hazardous Air Pollutants from Coal

Description: An improved process for removing mercury and other trace elements from coal containing pyrite by forming a slurry of finely divided coal in a liquid solvent capable of forming ions or radicals having a tendency to react with constituents of pyrite or to attack the bond between pyrite and coal and/or to react with mercury to form mercury vapors, and heating the slurry in a closed container to a temperature of at least about 50.degree. C. to produce vapors of the solvent and withdrawing vapors including solvent and mercury-containing vapors from the closed container, then separating mercury from the vapors withdrawn.

Status: Patent No. 6,156,281

Visit: <USPTO Page>

Nanotechnology

(Drug Delivery Methods)

Akala, Emmanuel;

Adesina, Simeon

Biodegradable Stealth Polymeric Nanoparticles for Improved Drug Delivery

Description: The invention is a novel method for producing polymer nanoparticles that can remain in the body’s circulation for longer periods of time than existing nanoparticle delivery systems. This technology allows for a greater amount of a therapeutic or diagnostic agent to reach targeted tissue and for more consistent dosing. Additionally, these nanoparticles can be modified for active delivery of cancer drugs to solid tumors or specific cell types. This is one of two inventions in the system.

Status: Patent No. 8,772,355, Application Published

Visit: <USPTO Page> <WIPO Application Page> <Marketing Document>.

Nanotechnology

(Drug Delivery Methods)

Akala, Emmanuel;

Okunola, Oluyomi;

 

Degradable Stealth Nanospheres for Improved Drug Delivery

Description: The invention is a novel method for producing polymer nanoparticles that can remain in the body’s circulation for longer periods of time than existing nanoparticle delivery systems. This technology allows for a greater amount of a therapeutic or diagnostic agent to reach targeted tissue and for more consistent dosing. Additionally, these nanoparticles can be modified for active delivery of cancer drugs to solid tumors or specific cell types. This is one of two inventions in the system.

Status: Patent No. 8,921,429, Application Published

Visit: <USPTO Page> <WIPO Application Page> <Marketing Document>

Nanotechnology

(Optics, Particle Detection)

Bates, Clayton

External Photoemissive Detector for Long Infrared Wavelengths

Description: This technology is an improved method of detecting long infrared wavelengths. Its advantages include its ability to detect extremely low energy photons, provide extremely fast response time and obtain high gains with low noise, thus enabling the detection of single photon events reliably. The detector also eliminates the need for a heterojunction barrier and the necessity of keeping the detector under good vacuum during its operating life. Commercial applications for this invention include military/security detection and surveillance, medical imaging, monitoring of pollutants, and semiconductor processing.

Status: Patent No. 8,154,028.

Visit: <USPTO Page> <Marketing Document>

Nanotechnology

(Optics, Optic-Electronics, Satellites, Information Infrastructure)

Huber, Tito

Nanothermocouple Single-Photon
Color-Sensitive Uncooled Light Detector

Description: This invention enables quantum detection at room temperature without the use of the cryogenic cooling systems typically required to deploy such devices. Control of the heat produced by the light sensing device is performed using bismuth telluride (BiTe), the material shown to have the highest thermoelectric efficiency at room temperature. Furthermore, forming BiTe as nanowires creates a thermocouple with a very low thermal mass that further increases thermoelectric efficiency.

Status: Patent No. 8,525,095.

Visit: <USPTO Page> <Marketing Document>

Nanotechnology

(Industrial Lubricants)

Mosleh, Mohsen Gelling Nanofluids for Dispersion Stability

Description: Below-room-temperature and at-room-temperature gelling of nanofluids for dispersion stability and prolonged shelf life without particle settlement.

Status: Patent Pending.

Visit: <Marketing Document>

Nanotechnology

(Industrial Lubricants)

Mosleh, Mohsen

Belk, John (The Boeing Co.)

Metal Forming Fluids with Dispersed Nanoparticles for Improved Lubrication

Description: New method for making sheet metal forming fluids with improved anti-wear properties through solid lubricant nanoparticles dispersed by sonication.

Status: Patent Pending, Application Published, Co-Developed with Support from the Boeing Company.

Visit: <WIPO Application Page> <Marketing Document>

Nanotechnology

(Industrial Lubricants)

Mosleh, Mohsen Nanolubricant Formulations for Extending Elastohdrodynamic and Hydrodynamic Lubrication Regimes and Lowering Friction

Description: This is a new method for making sheet metal forming fluids with improved anti-wear properties through solid lubricant nanoparticles dispersed by sonication. It focuses on preventing wear to the hard surfaces of forming dies while providing conventional lubrication to the softer product being formed. The result of this innovation is greater efficiency, longer tooling life, and lower costs. Commercial applications include any manufacturing in which metals rub up against one another.

Status: Patent Pending, Application Published

Visit: <WIPO Application Page> <Marketing Document>

Nanotechnology

(Industrial Lubricants)

Mosleh, Mohsen Surface Conditioning Nano-Lubricant (Hybrid Nano-Lubricants for Improved Lubrication and Heat Transfer)

Description: A nano-lubricant composition where the lubricant composition includes a flowable oil or grease with nanoparticles dispersed in the flowable oil or grease. The nanoparticles are configured to polish a surface of a structure slowly over a period of time. The nanoparticles have a hardness of at least about 7 Mohs and a diameter that is less than one half the arithmetic average roughness of the surface or a length that is less than one half of the arithmetic average roughness of the surface.

Status: Patent Pending, Application Published

Visit: <WIPO Application Page> <Marketing Document>

Medical Treatment Technology

(Chagas Disease Treatments, Trypanosome)

Bakare, Olodapo;

Lee, Clarence;

Brandy, Yakini;

Khraiwesh, Mozna

Method for Inhibiting Trypansoma Cruzi (Chagas Disease)

Description: Chagas disease is caused by the parasite Trypanosoma Cruzi, and consists of an acute phase that lasts weeks or months. Left untreated, it can lead to a chronic phase that may remain latent for up to 20 years. The current treatment, benznidazole and nifurtimox, have serious side effects, are time-intensive, and are ineffective during the chronic phase of the disease. Moreover, after 40 years of use, traditional medications are being met with parasitic resistance. This technology identifies a family of imido-substituted 1,4-naphthoquinone compounds that have demonstrated a several-fold higher toxicity than nifurtimox against T. cruzi, as well as more benign activity against mouse fibroblasts. These compounds have been subject to preliminary toxicity profiling in vivo in mice, but further study is needed.

Status: Patent Pending, Application Published

Visit: <WIPO Application Page> <Marketing Document>

Medical Treatment Technology

(Leishmaniasis Treatments)

Bakare, Olodapo;

Lee, Clarence;

Brandy, Yakini;

Manka, Cheu

Method for Treating Leishmaniasis

Description: This work identifies a family of imido-substituted 1,4-naphthoquinone compounds with activity against Leishmania donovani, the parasite that causes Leishmaniasis. Specifically, the family of compounds exhibits improved toxicity versus cultured L. donovani, and increased selectivity when compared with its toxicity toward fibroblasts. These new compounds have the potential to be used as either a prophylactic or therapeutic treatment. Since Leishmaniasis is a disease that predominantly afflicts individuals in developing countries and the current treatment is costly, time intensive and has serious side effects, there are incentives to find new effective therapeutics.

Status: Patent Pending, Application Published

Visit: <WIPO Application Page> <Marketing Document>

Medical Treatment Technology

(Endophthalmitis and Glaucoma)

Karla, Pradeep;

Mangat, Harpal

Method for Treating Endophthalmitis and Glaucoma

Description: The cornea, which contains efflux pumps as well as tight junctions between cells, acts as an efficient barrier to intraocular drug delivery. Thus, only a small percentage of a drug applied topically can cross this barrier to reach the anterior space of the eye. This invention is used for treating conditions of the retina. It calls for the addition of a drug efflux inhibitor to a normal therapeutic regimen to increase the bioavailability of the medication. It could be applicable to various conditions including endophthalmitis, glaucoma, macular degeneration, and diabetic retinopathy.

Status: Patent Pending, Application Published

Visit: <WIPO Application Page> <Marketing Document>

Medical Treatment Technology

(HIV/AIDS)

Karla, Pradeep Methods of Reducing HIV Transmission /Infection and Compositions Effective for Reducing HIV Transmission and Infection

Description: The inventor has discovered the presence of potent ABC drug efflux transporters on CD4+ T-cells, the initial site of human HIV infection. These efflux transporters lead to poor intracellular HIV drug concentrations. This is a novel therapeutic target for a new class of drugs that would consist of an efflux transporter inhibitor along with a NRTI, NNRIT or PI. The inventor has demonstrated a significant increase (³ two-fold) in the intracellular drug concentration by using the aforementioned combination. Currently, commercial application is focused on the development of a vaginal microbiocidal gel.

Status: Patent Pending

Visit: <Marketing Document>

Medical Treatment Technology

(Reperfusion Injury)

Mangat, Harpal

Karla, Pradeep

Composition and Method for Treating Ischemic Neuron Reperfusion Injury

Description: Ischemia can harm an organ by impeding blood flow. The reciprocal mechanism of ischemia, reperfusion, can also have several deleterious effects on an organ, including an increase in intracellular calcium. Although Dantrolene is the traditional method used to prevent or minimize neuronal cell damage caused by an increase of calcium during the reperfusion stage, it is not effective in all cases. Dantrolene alone is not effective at protecting neurons affected by nerve gas attack or traumatic brain injury (TBI), including certain types of stroke. Furthermore, in the case of nerve gas attack, the preferred method of delivery is through a nebulizer or gas mask. However, current Dantrolene is too harmful to the lungs to make this a good option. This invention, a combination of Dantrolene with a residue of FMOC-valine, can prevent the detrimental rise of intracellular calcium in nerve gas attack and TBI. Moreover, it can be delivered through a gas mask or nebulizer.

Status: Patent No. 8,993,512 & 9,248,118

Visit: <USPTO Page> <Marketing Document>

Medical Treatment Technology

(Degenerative Brain Conditions)

Nwulia, Evaristus;

Kulkarni, Amol;

 

Curcumin Compounds for the Treatment of HIV Dementia

Description: Research has been done on curcumin as a possible treatment for HIV-related brain dysfunction. However, bioavailability of this compound to the brain is limited when administered orally. This invention is lipophilic curcumin analogs that show increased solubility and dispersibility, and protect neurons via increased levels of chemicals such as brain-derived neurotrophic factor (BDNF). The analogs are delivered intranasally, traveling directly to the brain via the olfactory nerve, using an olfactory neuroplastic device along with a nasal cannula. Can be delivered directly to the olfactory nerves via Howard University's Olfactory Stimulation System Technology.

Status: Patent No. 9,012,490

Visit: <Marketing Document> <USPTO Website>

Medical Treatment Technology

(Degenerative Brain Conditions)

Nwulia, Evaristus;

Segun, Omoniyi

Olfactory Stimulation System for Neurological Disease Description: This invention is a device that can deliver novel, beneficial combinations of olfactory stimulative aromas to patients suspected of suffering from early cognitive decline. The Olfactory Neuroplastic Device (OND), as this technology is called, deliveries aroma stimulation through a portable mechanical pump that can be used for all or part of the day. The device has been used to improve verbal and cognitive skills in two patients. Further human trials are scheduled.

Status: Patent No. 9,101,652

Visit: <Marketing Document> <USPTO Website>

Medical Treatment Technology

(Dental, Cavity Filling)

Wang, Tongxin

Chow, Laurence

Bioactive Dental Composites for Tooth Fillings

Description: This technology consists of bioactive fillers as well as new coupling agents specifically for this bioactive filler. This composite is not only bioactive, but can also enhance the remineralization process, reducing the gap between materials and tooth.  These new dental composites have shown to have a low rate of degradation, long service life time, high bioactive property, re-mineralizing potential, and self-healing capability. The end result being effective restoration avoiding unnecessary, expensive replacement.

Status: Patent Pending

Visit: <Marketing Document>

Medical Treatment Technology

(Orthopedics, Bone Cement)

Wang, Tongxin;

Mitchell, James;

Lei, Yanda

Improved Calcium Phosphate and Polylactic Acid Bone Cements

Description: Dr. Wang and colleagues have identified methods of combining calcium phosphate with polylactic acid (PLA) that provide required strength and flexibility properties for use as an improved bone cement.

Status: Two (2) Patents Pending

Visit: <Marketing Document>

Pharmaceuticals

(Small Molecule Therapies, Cancer Treatments)

Bakare, Olodapo Prodrugs for Cancer Treatment

Description: Although emetine has proven to be cytotoxic to cancer cells, it has also exhibited general cytotoxic properties that make it nonviable as a therapeutic. This invention links protective groups to the emetine structure that prevent systemic side effects that normally occur. The protective groups are liberated upon encountering chemical or enzymatic changes such as those present in the tumor microenvironment. Thus the new compounds provide targeted chemotherapy, ameliorating non-specific exposure and causing cytotoxicity only to the tumor itself. These compounds may have application in multiple cancer types including breast cancer, prostate cancer, lung cancer, and leukemia.

Status: Patent Pending, Application Published

Visit: <WIPO Application Page> <Marketing Document>

Pharmaceuticals

(Amodiaquine Manufacture, Malaria Drugs)

Fortunak, Joseph;

Kulkarni, Amol;

King, Christopher

 

Efficient, Inexpensive, Green Synthesis of the Malaria Drug Amodiaquine Description: Malaria treatment currently requires synthesizing the drug amodiaquine with its analogs in a three to four step process that can take up to five days to complete. This process produces a 60-65% yield, and generates environmentally hazardous solvents. Howard University has invented an alternative synthesis method that is less expensive, has a higher yield of 90%, and has a lower environmental impact. It requires only a single vessel, can be completed in a single day and requires fewer solvents and reagents.

Status: Patent Pending, Application Published

Visit: <WIPO Application Page> <Marketing Document>

Pharmaceuticals

(Small Molecule Treatments, Ebola)

Nekhai, Sergei;

Kovalskyy, Dunytro

Inhibitors of Protein Phosphatase-1 for Ebola Treatment

Description: The inventors have identified a family of small molecules, host cell protein phosphatase-1 (PP1) inhibitors, that can be used to treat and/or prevent Ebola virus infection as well as decrease HIV1 replication. PP1 is needed for the dephosphorylation of VP30, a viral protein needed for Ebola virus replication. These PP1 inhibitors have been shown to prevent Ebola virus replication without any cellular toxicity. In the case of HIV-1, this treatment works by inhibiting the binding of HIV-1 Tat to PP1 host cell, which is required for HIV1 transcription.

Status: Patent Pending

Visit: <Marketing Document>

 

Pharmaceuticals

(Small Molecule Treatments, HIV, AIDS, Ebola)

Nekhai, Sergei;

Kovalskyy, Dunytro

Inhibitors of Protein Phosphatase-1 for HIV-1 Treatment

Description: The inventors have identified a family of small molecules, host cell protein phosphatase-1 (PP1) inhibitors, that can be used to treat and/or prevent Ebola virus infection as well as decrease HIV1 replication. PP1 is needed for the dephosphorylation of VP30, a viral protein needed for Ebola virus replication. These PP1 inhibitors have been shown to prevent Ebola virus replication without any cellular toxicity. In the case of HIV-1, this treatment works by inhibiting the binding of HIV-1 Tat to PP1 host cell, which is required for HIV1 transcription.

Status: Patent No. 8,278,326

Visit: <USPTO Page> <Marketing Document> <PowerPoint Presentation>

 

Pharmaceuticals

(Small Molecule Treatments, HIV, AIDS)

Nekhai, Sergei;

Kovalskyy, Dunytro

Iron Chelators as HIV-1 Inhibitors

Description: Elevated iron levels can allow the HIV-1 virus to replicate more rapidly and efficiently. Consequently, HIV-1 infected patients suffering from iron overload disease have a poor prognosis. The inventor has identified novel iron chelators that inhibit HIV-1 replication for patients with iron overload disease. These newly identified compounds can be administered in low doses, and have the potential to be less cytotoxic to patients than other iron chelators. Specifically, these new iron chelators decrease the activity of host cell CDK2, CDK9 and viral Tat, and can also induce expression of NF-kB inhibitor, IKBα, and HO-1.

Status: Patent Pending, Application Published

Visit: <WIPO Application Page>

Pharmaceuticals

(Small Molecule Treatments, Seizure)

Scott, Kenneth;

Nicholson, Jesse;

Edafiogho, Ivan

Enaminone Esters

Description: Novel synthetic organic compounds, enaminone esters, having distinct potent anticonvulsant activity with slight toxicity. .

Status: Patent No. 5,616,615

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Pharmaceuticals

(Meningitis Vaccines)

Tai, Stanley;

Lee, Robert (NIH)

Dual Meningitis Vaccine

Description: This vaccine formulation is an immunogenic composition for inducing antibodies to S. pneumoniae and N. meningitidis, providing dual protection against infections. The immunogenic composition may be administered to a subject by several different routes: intramuscular, intranasal, oral, sub-cutaneous, transdermal and transmucosal. With its dual protection, this vaccine reduces preparation and administration costs.

Status: Patent No. 8,003,112, Co-Commercialized with National Institutes of Health

Visit: <USPTO Patent Page> <Marketing Document>